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com Fast And Furious 7 Torrent Free Download as well as alternative to Fast And Furious 7 Movie Torrent. In this article we’ll bring you to download Fast And Furious 7 movie torrent file with fast and furti. HD Free Movies are easy to download, free of charge and no. 1 HD Movie Sites. No Signup, No Registration, No Downloads, No Ads. Скачай ссылка на скачивание фильма Fast. Fast And Furious 7 torrent or any other torrent from the.Hydroxytyrosol inhibits proliferation of fibroblasts in mice fibrotic liver via MAPK signaling pathway. Hepatic fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM), and transforming growth factor-beta (TGF-β)1 is the most powerful profibrogenic factor. Thus, therapy of hepatic fibrosis is an important research field. The aim of this study was to evaluate the effects of hydroxytyrosol (HT) on the proliferation of fibroblasts and the underlying molecular mechanism in a mouse model of hepatic fibrosis. Mice were divided into three groups: normal control group, hepatic fibrosis group, and HT-treated group. An in vitro model was established by treatment with 5 ng/mL TGF-β1 for 72 h in L-02 hepatocyte cell line and in 2 × 10(6) fibroblasts cell line, and a mouse model of hepatic fibrosis was induced by carbon tetrachloride (CCl4) treatment. Administration of HT effectively attenuated liver injury by increasing serum levels of albumin and aminotransferase, and decreased liver tissue levels of α-smooth muscle actin (α-SMA) and collagen I. A reduction of transforming growth factor-beta1, phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and mitogen-activated protein kinases (MAPKs) in the nucleus was observed in the HT-treated group. HT suppressed the production of collagen in vitro and in vivo and inhibited the TGF-β1-induced expression of fibronectin, α-SMA, and collagen I. Furthermore, HT suppressed the phosphorylation of Smad2/3 in the nucleus in a mouse model of hepatic fibrosis.

 

 


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